México.- Investigadores mexicanos lograron identificar los fármacos más tóxicos para el hígado, a través de un modelo computacional basado en inteligencia artificial, informó hoy el Instituto Tecnológico de Monterrey en un comunicado.
El método llamado TimeTGP, en el cual participaron también expertos del Instituto Nacional de Medicina Genómica, emplea minería de datos en series de tiempo para evaluar el efecto que genera cada posible compuesto o fármaco.
Esta herramienta integra también la información de múltiples dosis, tiempos y réplicas, lo cual permitió clasificar los fármacos por nivel de toxicidad.
Los investigadores concluyeron que la isoniazida, el acetaminofén, el fenobarbital, diclofenaco, la etionina y el isotiocianato de Naftilo son los químicos más dañinos para el hígado.
La principal preocupación es que al ser varios de estos medicamentos de venta libre, el usuario puede consumirlos y provocarse un daño a la salud de no usarlos de manera adecuada.
“En general, todos los fármacos tienen un cierto grado de toxicidad, pero es muy complejo detectar sus posibles efectos secundarios”, dijo Julieta Noguez, quien lideró junto con Claudia Rangel la investigación.
El sistema evalúa individualmente los fármacos, utilizando un proceso bayesiano, el cual ordena los genes con base en los cambios entre condiciones, tiempos y réplicas.
Posteriormente, el investigador puede realizar análisis sobre múltiples compuestos o fármaco y dosis de la base de datos, para evaluar las hipótesis generadas.
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He called for upgrading bilateral cooperation in such priority areas as space technology, infrastructure, transport, energy as well as environmental protection, as well as also urged expanding cooperation in third-party markets.
To deepen economic and trade cooperation, Li expects China as well as ASEAN to work with other relevant countries to substantially conclude negotiations on the Regional Comprehensive Economic Partnership (RCEP) at an early date, expand cooperation and reduce barriers to trade and investment.
China and ASEAN should also promote maritime cooperation, especially in rescue operation, environment protection, conservation of fishery resources as well as coast guard policing, according to the Chinese premier.
Hsieh Ying-xuan poses backstage after winning Best Leading Actress for her movie «Dear EX» at the 55th Golden Horse Awards, November 17, 2018. /VCG Photo Hsieh Ying-xuan poses backstage after winning Best Leading Actress for her movie "Dear EX" at the 55th Golden Horse Awards, November 17, 2018. /VCG Photo
ASEAN, with Singapore as its rotating chair this year, took a leading role in speeding up the talks on RCEP. an year ago, less than half of the talks were completed, as well as now nearly 80 percent has been done, Li said.
Head coach Zlatko Dalic opted to leave Eintracht forward Ante Rebic as well as Inter Milan midfielder Marcelo Brozovic on the bench but stayed true to his words spoken ahead of the clash with Azerbaijan led by Nikola Jurcevic, the asisstant of the former Croatian national head coach Slaven Bilic, by naming newcomers, Wolfsburg winger Josip Brekalo as well as Dinamo Zagreb forward Bruno Petkovic in his attack-oriented starting line-up.
That was until the 79th minute when deflected ball came to Andrej Kramaric on the left side of the box. Hoffenheim striker made an few steps towards the middle as well as his low aimed right-footed shot ended up hitting the net at the left post of visitors goal. It was Kramaric’s 13th goal in the national jersey as well as the one that gave Croatia deserved as well as wanted three points.
Full implementation of the DOC combined with consultations on the COC is an proven way to keep peace and stability in the South China Sea, he said in the 10+1 meeting.
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